N-halamine modified multiporous bacterial cellulose with enhanced antibacterial and hemostatic properties

Bacterial cellulose (BC) is a natural polymer with remarkable superiority for fabricating biomaterials. In this study, a multiporous bacterial cellulose (MBC) film was modified with N-isopropylacrylamide (NIPAM), and the modified MBC film was imbued with antibacterial properties after chlorination. The dried chlorinated samples showed superb antibacterial efficacy and could inactivate 6.19 log of inoculated S. aureus and 6.29 log of E. coli within 1 min of contact. After releasing active chlorine for 12 h, 3.67 log of S. aureus and 3.97 log of E. coli were inactivated within 30 min of contact. The prepared films displayed high porous and layered structures with a resultant excellent water retention which can be applied as material for wound dressings. In addition, the chlorinated films showed hemostatic ability on wound bleeding and good biocompatibility. The prepared N-halamine functionalized MBC films might have great potential applications as wound dressings.