Ascorbic acid regulates in vitro and in vivo toxicogenetic effects of hydroxyurea on eukaryotic cells
抗坏血酸
体内
体外
化学
生物化学
生物
细胞生物学
遗传学
食品科学
作者
Raí Pablo Sousa de Aguiar,Jéssica Maria Teles Souza,Ag‐Anne Pereira Melo de Menezes,Maria Luísa Lima Barreto do Nascimento,João Marcelo de Castro e Sousa,Ana Amélia de Carvalho Melo Cavalcante,Paulo Michel Pinheiro Ferreira,Ana Jérsia Araújo,José Delano Barreto Marinho Filho
Hydroxyurea (HU) exerts unique and diverse biological effects as an anti-leukemic agent, irradiation sensitizer, and HbS inducer in patients with sickle cell anemia. Herein, we assessed the potential toxicogenic and/or oxidant effects of hydroxyurea associated with ascorbic acid by