Enantioselective Construction of Oxindoles Bearing a Quaternary Carbon via Ni–Al Bimetal‐Catalyzed Formyl C–H Alkylation

Enantioselective transition metal‐catalyzed C–H alkylation emerges as one of the most atom‐ and step‐economical routes to chiral quaternary carbons, while big challenges still remain with acyl C–H alkylations. Herein, we use a Ni–Al bimetallic catalyst to facilitate a highly regioselective and highly enantioselective C–H alkylation of formamides with alkenes, constructing various oxindoles bearing a chiral quaternary carbon in up to 94% yield and up to 95% ee.