Review: Impact of Helicobacter pylori on Alzheimer's disease: What do we know so far?

疾病 幽门螺杆菌 医学 螺杆菌 免疫学 病理 内科学
作者
Michael Doulberis,Georgios Kotronis,Robert V. Thomann,Stergios A. Pοlyzos,Marina Boziki,Dimitra Gialamprinou,Georgia Deretzi,Panagiotis Katsinelos,Jannis Kountouras
出处
期刊:Helicobacter [Wiley]
卷期号:23 (1) 被引量:109
标识
DOI:10.1111/hel.12454
摘要

Abstract Background Helicobacter pylori has changed radically gastroenterologic world, offering a new concept in patients' management. Over time, more medical data gave rise to diverse distant, extragastric manifestations and interactions of the “new” discovered bacterium. Special interest appeared within the field of neurodegenerative diseases and particularly Alzheimer's disease, as the latter and Helicobacter pylori infection are associated with a large public health burden and Alzheimer's disease ranks as the leading cause of disability. However, the relationship between Helicobacter pylori infection and Alzheimer's disease remains uncertain. Methods We performed a narrative review regarding a possible connection between Helicobacter pylori and Alzheimer's disease. All accessible relevant (pre)clinical studies written in English were included. Both affected pathologies were briefly analyzed, and relevant studies are discussed, trying to focus on the possible pathogenetic role of this bacterium in Alzheimer's disease. Results Data stemming from both epidemiologic studies and animal experiments seem to be rather encouraging, tending to confirm the hypothesis that Helicobacter pylori infection might influence the course of Alzheimer's disease pleiotropically. Possible main mechanisms may include the bacterium's access to the brain via the oral‐nasal‐olfactory pathway or by circulating monocytes (infected with Helicobacter pylori due to defective autophagy) through disrupted blood‐brain barrier, thereby possibly triggering neurodegeneration. Conclusions Current data suggest that Helicobacter pylori infection might influence the pathophysiology of Alzheimer's disease. However, further large‐scale randomized controlled trials are mandatory to clarify a possible favorable effect of Helicobacter pylori eradication on Alzheimer's disease pathophysiology, before the recommendation of short‐term and cost‐effective therapeutic regimens against Helicobacter pylori ‐related Alzheimer's disease.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
xyj完成签到,获得积分10
刚刚
刚刚
孙燕应助Stardust采纳,获得10
刚刚
2秒前
NexusExplorer应助科研通管家采纳,获得10
2秒前
SciGPT应助科研通管家采纳,获得10
2秒前
科研通AI2S应助科研通管家采纳,获得10
2秒前
今后应助科研通管家采纳,获得10
3秒前
所所应助科研通管家采纳,获得10
3秒前
在水一方应助科研通管家采纳,获得10
3秒前
CAOHOU应助科研通管家采纳,获得10
3秒前
CAOHOU应助科研通管家采纳,获得10
3秒前
小马甲应助科研通管家采纳,获得20
3秒前
3秒前
3秒前
梅卡完成签到 ,获得积分10
4秒前
111发布了新的文献求助10
4秒前
酷波er应助飞快的夜天采纳,获得10
6秒前
6秒前
6秒前
范月月完成签到 ,获得积分10
7秒前
sirhai发布了新的文献求助10
8秒前
8秒前
NexusExplorer应助少敏敏采纳,获得10
8秒前
英姑应助罗拉采纳,获得10
10秒前
小爪冰凉发布了新的文献求助10
10秒前
10秒前
10秒前
苏孖发布了新的文献求助20
10秒前
Qi完成签到 ,获得积分10
11秒前
百事可乐完成签到 ,获得积分10
13秒前
李嘉欣发布了新的文献求助10
13秒前
小万完成签到,获得积分10
14秒前
Lucas应助开灯人和关灯人采纳,获得10
14秒前
怕孤独的冰淇淋完成签到,获得积分10
15秒前
禹与于发布了新的文献求助10
16秒前
persist发布了新的文献求助10
16秒前
向上发布了新的文献求助10
17秒前
量子星尘发布了新的文献求助10
17秒前
111完成签到,获得积分10
17秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989378
求助须知:如何正确求助?哪些是违规求助? 3531442
关于积分的说明 11254002
捐赠科研通 3270126
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809173