Review: Impact of Helicobacter pylori on Alzheimer's disease: What do we know so far?

疾病 幽门螺杆菌 医学 螺杆菌 免疫学 病理 内科学
作者
Michael Doulberis,Georgios Kotronis,Robert V. Thomann,Stergios A. Pοlyzos,Marina Boziki,Dimitra Gialamprinou,Georgia Deretzi,Panagiotis Katsinelos,Jannis Kountouras
出处
期刊:Helicobacter [Wiley]
卷期号:23 (1) 被引量:109
标识
DOI:10.1111/hel.12454
摘要

Abstract Background Helicobacter pylori has changed radically gastroenterologic world, offering a new concept in patients' management. Over time, more medical data gave rise to diverse distant, extragastric manifestations and interactions of the “new” discovered bacterium. Special interest appeared within the field of neurodegenerative diseases and particularly Alzheimer's disease, as the latter and Helicobacter pylori infection are associated with a large public health burden and Alzheimer's disease ranks as the leading cause of disability. However, the relationship between Helicobacter pylori infection and Alzheimer's disease remains uncertain. Methods We performed a narrative review regarding a possible connection between Helicobacter pylori and Alzheimer's disease. All accessible relevant (pre)clinical studies written in English were included. Both affected pathologies were briefly analyzed, and relevant studies are discussed, trying to focus on the possible pathogenetic role of this bacterium in Alzheimer's disease. Results Data stemming from both epidemiologic studies and animal experiments seem to be rather encouraging, tending to confirm the hypothesis that Helicobacter pylori infection might influence the course of Alzheimer's disease pleiotropically. Possible main mechanisms may include the bacterium's access to the brain via the oral‐nasal‐olfactory pathway or by circulating monocytes (infected with Helicobacter pylori due to defective autophagy) through disrupted blood‐brain barrier, thereby possibly triggering neurodegeneration. Conclusions Current data suggest that Helicobacter pylori infection might influence the pathophysiology of Alzheimer's disease. However, further large‐scale randomized controlled trials are mandatory to clarify a possible favorable effect of Helicobacter pylori eradication on Alzheimer's disease pathophysiology, before the recommendation of short‐term and cost‐effective therapeutic regimens against Helicobacter pylori ‐related Alzheimer's disease.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
mc完成签到 ,获得积分10
刚刚
量子星尘发布了新的文献求助10
3秒前
4秒前
4秒前
虚幻谷波完成签到,获得积分10
6秒前
ruochenzu发布了新的文献求助10
9秒前
小马甲应助搞怪梦寒采纳,获得10
11秒前
firewood完成签到 ,获得积分10
12秒前
天天快乐应助普鲁卡因采纳,获得10
14秒前
orixero应助NXK采纳,获得10
14秒前
bjr完成签到 ,获得积分10
16秒前
研友_LwlAgn完成签到,获得积分10
20秒前
陈昊完成签到,获得积分10
28秒前
29秒前
tian发布了新的文献求助10
31秒前
34秒前
34秒前
龙舞星完成签到,获得积分10
35秒前
36秒前
王涉发布了新的文献求助10
38秒前
普鲁卡因发布了新的文献求助10
39秒前
量子星尘发布了新的文献求助10
41秒前
柚子完成签到,获得积分10
45秒前
46秒前
马儿饿了要吃草完成签到,获得积分10
46秒前
48秒前
sudor123456完成签到,获得积分10
53秒前
NXK发布了新的文献求助10
53秒前
打打应助普鲁卡因采纳,获得10
56秒前
58秒前
lii完成签到,获得积分10
58秒前
jiaolulu发布了新的文献求助10
1分钟前
个性惜蕊完成签到,获得积分10
1分钟前
1分钟前
轩辕书白完成签到,获得积分10
1分钟前
qinzhikai完成签到,获得积分10
1分钟前
天真的冬瓜完成签到,获得积分10
1分钟前
小溜溜完成签到 ,获得积分10
1分钟前
普鲁卡因发布了新的文献求助10
1分钟前
tian发布了新的文献求助10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038112
求助须知:如何正确求助?哪些是违规求助? 3575788
关于积分的说明 11373801
捐赠科研通 3305604
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022