催化作用
化学
活动站点
纳米材料
Atom(片上系统)
计算机科学
组合化学
材料科学
纳米技术
有机化学
嵌入式系统
作者
Liang Huang,Jinxing Chen,Linfeng Gan,Jin Wang,Shaojun Dong
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2019-05-03
卷期号:5 (5)
被引量:743
标识
DOI:10.1126/sciadv.aav5490
摘要
Conventional nanozyme technologies face formidable challenges of intricate size-, composition-, and facet-dependent catalysis and inherently low active site density. We discovered a new class of single-atom nanozymes with atomically dispersed enzyme-like active sites in nanomaterials, which significantly enhanced catalytic performance, and uncovered the underlying mechanism. With oxidase catalysis as a model reaction, experimental studies and theoretical calculations revealed that single-atom nanozymes with carbon nanoframe-confined FeN5 active centers (FeN5 SA/CNF) catalytically behaved like the axial ligand-coordinated heme of cytochrome P450. The definite active moieties and crucial synergistic effects endow FeN5 SA/CNF with a clear electron push-effect mechanism, as well as the highest oxidase-like activity among other nanozymes (the rate constant is 70 times higher than that of commercial Pt/C) and versatile antibacterial applications. These suggest that the single-atom nanozymes have great potential to become the next-generation nanozymes.
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