祖细胞
干细胞
再生医学
再生(生物学)
骨髓
细胞生物学
生物
间充质干细胞的临床应用
细胞
成体干细胞
医学
免疫学
内皮干细胞
癌症研究
体外
遗传学
作者
Robert C. Rennert,Michael Sorkin,Ravi K. Garg,Geoffrey C. Gurtner
出处
期刊:Regenerative Medicine
[Future Medicine]
日期:2012-11-01
卷期号:7 (6): 833-850
被引量:148
摘要
Tissue repair and regeneration are thought to involve resident cell proliferation as well as the selective recruitment of circulating stem and progenitor cell populations through complex signaling cascades. Many of these recruited cells originate from the bone marrow, and specific subpopulations of bone marrow cells have been isolated and used to augment adult tissue regeneration in preclinical models. Clinical studies of cell-based therapies have reported mixed results, however, and a variety of approaches to enhance the regenerative capacity of stem cell therapies are being developed based on emerging insights into the mechanisms of progenitor cell biology and recruitment following injury. This article discusses the function and mechanisms of recruitment of important bone marrow-derived stem and progenitor cell populations following injury, as well as the emerging therapeutic applications targeting these cells.
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