Copper‐Mediated Difluoromethylation of (Hetero)aryl Iodides and β‐Styryl Halides with Tributyl(difluoromethyl)stannane

Angewandte Chemie International EditionVolume 51, Issue 48 p. 12090-12094 Communication Copper-Mediated Difluoromethylation of (Hetero)aryl Iodides and β-Styryl Halides with Tributyl(difluoromethyl)stannane† Prof. Dr. G. K. Surya Prakash, Corresponding Author Prof. Dr. G. K. Surya Prakash [email protected] Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)Search for more papers by this authorDr. Somesh K. Ganesh, Dr. Somesh K. Ganesh Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)Search for more papers by this authorJohn-Paul Jones, John-Paul Jones Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)Search for more papers by this authorDr. Aditya Kulkarni, Dr. Aditya Kulkarni Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)Search for more papers by this authorKamil Masood, Kamil Masood Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)Search for more papers by this authorJoseph K. Swabeck, Joseph K. Swabeck Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)Search for more papers by this authorProf. Dr. George A. Olah, Prof. Dr. George A. Olah Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)Search for more papers by this author Prof. Dr. G. K. Surya Prakash, Corresponding Author Prof. Dr. G. K. Surya Prakash [email protected] Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)Search for more papers by this authorDr. Somesh K. Ganesh, Dr. Somesh K. Ganesh Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)Search for more papers by this authorJohn-Paul Jones, John-Paul Jones Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)Search for more papers by this authorDr. Aditya Kulkarni, Dr. Aditya Kulkarni Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)Search for more papers by this authorKamil Masood, Kamil Masood Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)Search for more papers by this authorJoseph K. Swabeck, Joseph K. Swabeck Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)Search for more papers by this authorProf. Dr. George A. Olah, Prof. Dr. George A. Olah Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)Search for more papers by this author First published: 25 October 2012 https://doi.org/10.1002/anie.201205850Citations: 280 † Financial support by the Loker Hydrocarbon Research Institute is gratefully acknowledged. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract Owing to their unique properties, molecules containing the difluoromethyl group (CF2H) are of great interest. Tributyl(difluoromethyl)stannane has now been used for the selective and efficient direct ipso difluoromethylation of aryl iodides, heterocyclic iodides, and β-styryl halides (see scheme). The straightforward preparation of the difluoromethylating reagent makes this approach particularly valuable. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_201205850_sm_miscellaneous_information.pdf4.1 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume51, Issue48November 26, 2012Pages 12090-12094 RelatedInformation