败血症
香兰素
谷胱甘肽
医学
氧化应激
脾脏
H&E染色
盲肠
炎症
药理学
染色
内科学
免疫学
化学
酶
生物化学
病理
作者
Alok Shiomurti Tripathi,Saumya Awasthi,Rahul Kumar Maurya,Mohammad Yasir,Lucy Mohapatra,Vivek Kumar Srivastav
标识
DOI:10.1016/j.micpath.2022.105493
摘要
Present investigation evaluates the protective effect of vanillin against sepsis. Sepsis was induced by cecal ligation and puncture (CLP) in rat and vanillin was administered at dose of 100 and 200 mg/kg p.o. for five days after induction of sepsis. Effect of vanillin was observed on the percentage of survival, body weight and food intake were determined in CLP induced sepsis rats. Level of liver enzymes in the serum and organ weight was also observed in vanillin treated CLP induced rats. Moreover, histopathological changes were also observed in liver and lung tissue of hematoxylin and eosin (H&E) staining. There was significant improvement in bodyweight and food intake in vanillin treated group than negative control group after the sepsis induction. Moreover, vanillin improves the percentage of survival rate and reduces the level of liver enzymes and spleen weight in CLP induced sepsis rat. It also improves the level of glutathione (GSH) compared to negative control group. In conclusion, data of investigation reveals that vanillin ameliorates the survival rate and oxidative stress in CLP induced sepsis rat model.
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