牙周炎
牙槽
纳米反应器
体内
脂多糖
药物输送
免疫系统
牙龈和牙周袋
炎症
抗生素
牙缺失
医学
牙科
微生物学
免疫学
化学
生物
材料科学
纳米技术
纳米颗粒
生物技术
有机化学
口腔健康
作者
Lihua Xu,Shileng Chen,Yushuo Feng,Ming Chen,Yaqing Liu,Xiaoqian Ma,Jinpeng Jing,Shanshan Meng,Youliang Yao,Wenjing Sun,Hongmin Chen
标识
DOI:10.1002/adtp.202200230
摘要
Abstract Periodontitis, one of the most common dental diseases, is the main cause of tooth loss. Bacterial infection and the host immune response are the dominant factors that determine periodontal disease. Therefore, the key factors in the treatment of periodontitis are to remove pathogenic factors and repair periodontal supporting tissues. In this work, a facile and versatile strategy to prepare pH‐sensitive biomineralized nanoparticles constructed with antibiotic to simultaneously deliver antibacterial, anti‐inflammatory, and bone repair capabilities is presented. The experiments in vitro show that the nanoreactor achieves good inhibitory effects on three common periodontal pathogens and has activity against damaging inflammatory mediators, reducing lipopolysaccharide‐induced inflammatory responses. In vivo CT images of the maxillary molar area and histomorphological and immunohistochemical analyses demonstrate that the nanoparticles repair function for periodontal supporting tissues, reverse the loosened alveolar bone tissue, and remodel the periodontal inflammatory microenvironment. Therefore, the present research provides a feasible approach to both prevent the loss of alveolar bone and repair periodontal tissue.
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