Stereoselective synthesis of 1,2-bis(boronates)

1,3-Stereogenic centers are prevalent scaffolds in drugs and bioactive molecules. However, the direct assembly of these chiral centers through asymmetric catalysis poses difficulties, primarily due to the challenge of achieving stereoselectivity when the nucleophiles are remote from chiral environment. Recently, our group has developed an efficient method to synthesize chiral 1,2-bis(boronic) esters, allowing the formation of acyclic, non-adjacent 1,3-stereocenters with high levels of chemo-, regio-, enantio-, and diastereoselectivity.