表观遗传学
DNA甲基化
组蛋白
生物
染色质
宫颈癌
癌症
基因
生物信息学
基因表达调控
人乳头瘤病毒
基因表达
计算生物学
遗传学
癌症研究
作者
Hui Liu,Hongbing Ma,Yang Li,Hua Zhao
标识
DOI:10.1016/j.bbcan.2023.188894
摘要
Cervical cancer (CC) is an important public health problem for women, and perspectives and information regarding its prevention and treatment are quickly evolving. Human papilloma virus (HPV) has been recognized as a major contributor to CC development; however, HPV infection is not the only cause of CC. Epigenetics refers to changes in gene expression levels caused by non-gene sequence changes. Growing evidence suggests that the disruption of gene expression patterns which were governed by epigenetic modifications can result in cancer, autoimmune diseases, and various other maladies. This article mainly reviews the current research status of epigenetic modifications in CC based on four aspects, respectively DNA methylation, histone modification, noncoding RNA regulation and chromatin regulation, and we also discuss their functions and molecular mechanisms in the occurrence and progression of CC. This review provides new ideas for early screening, risk assessment, molecular targeted therapy and prognostic prediction of CC.
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