Endogenous stimulus-controlled estradiol@AIEgen-based covalent organic framework for reduction of myocardial ischemia/reperfusion injury

ATP stimulus-responsive tetrahedral DNA-gated fluorescent covalent organic frameworks (COFs) were developed for estradiol (E2) delivery and controllable release. The fluorescent COFs with an efficient E2 loading showed great potential against myocardial ischemia and reperfusion injury.