Exacerbation during the first year of treatment affects lung function in subjects with asthma - a 10-year follow-up.

医学 哮喘 肺功能 恶化 哮喘恶化 肺功能测试 内科学 物理疗法 儿科
作者
Paula Almeida,Eduardo Vieira Ponte,Rafaël Stelmach,TW Harrison,Nicola Scichilone,Adelmir Souza‐Machado,AA Cruz
出处
期刊:Journal of Asthma [Taylor & Francis]
卷期号:: 1-14
标识
DOI:10.1080/02770903.2025.2451690
摘要

Inhaled corticosteroids (ICS) are the preferred treatment for asthma. They improve symptoms and reduce exacerbations and deaths, but their long-term impact on lung function loss remains unclear, especially after delayed treatment. We aimed to characterize the lung function trajectories in subjects with previously untreated severe asthma. The secondary aim was to identify predictors of FEV1 decline, and future exacerbations. This is a post-hoc analysis that followed 184 subjects with asthma for 10 years after a delayed start of regular maintenance ICS treatment. Absolute lung function variation was calculated using two different baselines: (i) FEV1 after one year of regular treatment (V1) and (ii) best FEV1 observed any time before the final visit. Most individuals were female (84%) over 50 years old and had early-onset asthma with a median of 30 years without regular ICS treatment. Ninety-nine (54%) had an FEV1 decline above 25ml/year, using strategy (i). Those subjects were younger, had shorter duration of asthma, and had better lung function at V1. Most of the participants without any obstructive pattern (74%) or with mild obstruction (64%) at V1 showed a faster absolute FEV1 decline, however PRISm showed faster relative decline than the other groups. Therefore, this study showed improved symptoms and quality of life with variable lung function trajectories among individuals with asthma who start regular treatment after decades of delay. Additionally, exacerbation during the first year was a strong predictor of absolute FEV1 decline and future exacerbations, while time without treatment was a predictor of relative reduction of FEV1.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
2秒前
2秒前
aifd完成签到,获得积分10
3秒前
3秒前
每天都在找完成签到,获得积分10
5秒前
5秒前
6秒前
淡烟流水发布了新的文献求助10
7秒前
7秒前
小李发布了新的文献求助30
8秒前
汉堡包应助明芬采纳,获得30
8秒前
爆米花应助彭栋采纳,获得10
8秒前
9秒前
9秒前
MeiyanZou完成签到 ,获得积分10
9秒前
12秒前
12秒前
潇湘雪月发布了新的文献求助10
13秒前
13秒前
13秒前
14秒前
感动黄豆发布了新的文献求助10
14秒前
hhhblabla应助东方红采纳,获得10
16秒前
Poker应助sb采纳,获得10
17秒前
Ginger发布了新的文献求助10
17秒前
吃骨头的猫完成签到,获得积分10
17秒前
小李完成签到,获得积分10
17秒前
17秒前
18秒前
明芬发布了新的文献求助30
20秒前
20秒前
Smile完成签到,获得积分10
20秒前
Chaoe完成签到,获得积分10
23秒前
建国发布了新的文献求助10
24秒前
闪闪w发布了新的文献求助10
27秒前
淡烟流水完成签到,获得积分10
27秒前
俏皮芷蕊完成签到,获得积分10
28秒前
完美世界应助忐忑的阑香采纳,获得10
28秒前
华仔应助兴奋千兰采纳,获得10
33秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989115
求助须知:如何正确求助?哪些是违规求助? 3531367
关于积分的说明 11253688
捐赠科研通 3269986
什么是DOI,文献DOI怎么找? 1804868
邀请新用户注册赠送积分活动 882078
科研通“疑难数据库(出版商)”最低求助积分说明 809105