炎症
伤口愈合
氧化应激
免疫系统
自噬
材料科学
自愈水凝胶
生物医学工程
体内
化学
细胞生物学
药理学
癌症研究
医学
细胞凋亡
免疫学
生物化学
生物
生物技术
高分子化学
作者
Shen Tian,Jiawei Mei,Lisha Zhang,Senyan Wang,Yuhui Yuan,Jia Li,Hongjian Liu,Wanbo Zhu,Dongdong Xu
出处
期刊:Small
[Wiley]
日期:2024-10-03
标识
DOI:10.1002/smll.202407340
摘要
Abstract Oxidative stress, chronic inflammation, and immune senescence are important pathologic factors in diabetic wound nonhealing. This study loads taurine (Tau) into cerium dioxide (CeO 2 ) to develop CeO 2 @Tau nanoparticles with excellent antioxidant, anti‐inflammatory, and anti‐aging properties. To enhance the drug penetration efficiency in wounds, CeO 2 @Tau is encapsulated in gelatin methacryloyl (GelMA) hydrogel to prepare CeO 2 @Tau@Hydrogel@Microneedle (CTH@MN) patch system. Microneedle technology achieves precise and efficient delivery of CeO 2 @Tau, ensuring their deep penetration into the wound tissue for optimal efficacy. Rigorous in vitro and in vivo tests have confirmed the satisfactory therapeutic effect of CTH@MN patch on diabetic wound healing. Mechanistically, CTH@MN attenuates oxidative damage and inflammatory responses in macrophages by inhibiting the ROS/NF‐κB signaling pathway. Meanwhile, CTH@MN activated autophagy‐mediated anti‐aging activity, creating a favorable immune microenvironment for tissue repair. Notably, in a diabetic mouse wound model, the multifunctional CTH@MN patch significantly promotes wound healing by systematically regulating the oxidation‐inflammation‐aging (oxi‐inflamm‐aging) pathological axis. In conclusion, the in‐depth exploration of the CTH@MN system in this study provides new strategies and perspectives for treating diabetic non‐healing wounds.
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