医学
药品
脑病
药物输送
淋巴系统
神经科学
病理
药理学
疾病
心理学
化学
有机化学
作者
Rohit Sharma,Monika,Bobby Tyagi,Disha Gupta,Rupa Mazumder,Avijit Mazumder
出处
期刊:Central nervous system agents in medicinal chemistry
[Bentham Science]
日期:2024-10-15
卷期号:25
标识
DOI:10.2174/0118715249329586240924105624
摘要
Abstract: Brain-related Neurodegenerative Disorders (NDD) are the leading cause of low life expectancy globally. Brain-targeted drug delivery is required for treating most the NDD via bypassing the blood-brain barrier, and hepatic first-pass metabolism. The nasal-brain drug delivery route has the advantage of locally enhancing drug delivery to the brain, mainly through the olfactory route rather than systemic circulation. To overcome the limitations of nasal-brain drug delivery, a nanocarrier approach and mucoadhesive polymers are needed. Notwithstanding these constraints, various nanotechnology techniques have been created, including polymeric micelles, liposomes, polymeric nanoparticles, solid lipid nanoparticles, & nano-emulsions. This review aims to explore the intranasal pathway for drug delivery through the nasal-brain lymphatic systems, considering brain anatomy and physiology along with a drug formulation design approach.
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