单克隆抗体
免疫疗法
医学
抗体
癌症
免疫学
临床疗效
双特异性抗体
内科学
作者
Yin Yao,Yiyin Hu,Fei Wang
出处
期刊:Immunology
[Wiley]
日期:2023-03-08
卷期号:169 (4): 389-399
被引量:7
摘要
Despite the clinical success of monoclonal and bispecific antibodies, there are still limitations in the therapeutic effect of malignant tumours, such as low response rate, treatment resistance, and so on, inspiring the exploration of trispecific antibodies (TsAbs). TsAbs further improve the safety and efficacy and has great clinical potential through three targets combination and formats optimization. This article reviews the development history and the target combination features of TsAbs. Although there are still great challenges in the clinical application of TsAbs, it is undeniable that TsAbs may be a breakthrough in the development of antibody drugs.
科研通智能强力驱动
Strongly Powered by AbleSci AI