三醋酸纤维素
血液滤过
医学
血小板
血小板活化
肝素
并发症
肾脏替代疗法
重症监护室
聚砜
低分子肝素
泌尿科
外科
血液透析
内科学
纤维素
膜
化学
生物化学
作者
Shuangxin Liu,Wei Shi,Xinling Liang,Yong Su,Yongzhen Liang,Bin Zhang,Zhiming Ye,Lixia Xu,Yunfeng Xia,Chaoshen He,Jianchao Ma,Yiming Tao,Hen Ye,Hui Li
出处
期刊:Blood Purification
[S. Karger AG]
日期:2010-05-20
被引量:11
摘要
Thrombocytopenia is a common complication in patients receiving continuous veno-venous hemofiltration (CVVH) in the intensive care unit. The hemofilter itself plays an important role in the genesis of thrombocytopenia. The present study was undertaken to test whether there were differences in platelet loss and activation during CVVH with a polysulfone (PS) hemofilter or a cellulose triacetate (CTA) dialyzer. 96 patients with thrombocytopenia and acute kidney injury requiring CVVH were randomly assigned to four groups receiving low-molecular-weight heparin (LMWH) PS (n = 24), LMWH CTA (n = 24), no anticoagulation PS (n = 24), and no anticoagulation CTA (n = 24), respectively. We found a significant decrease in platelet counts, but an increased platelet activation with the PS hemofilter in patients who received no anticoagulation. There was no significant decrease in platelet counts and activation in the CTA group. The cellulose membranes could be an effective alternative to the standard synthetic membranes in patients at high risk for thrombocytopenia during CVVH.
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