化脓性汗腺炎
发病机制
免疫学
补体系统
免疫系统
医学
免疫失调
大疱性类天疱疮
替代补体途径
疾病
抗体
病理
作者
Mondana Ghias,Michael J. Hyde,Lewis E. Tomalin,B. Paul Morgan,Afsáneh Alavi,Michelle A. Lowes,Vincent Piguet
标识
DOI:10.1016/j.jid.2019.09.009
摘要
Although the role of immune dysregulation in hidradenitis suppurativa (HS) has yet to be elucidated, recent studies identified several complement abnormalities in patients with HS. The complement system serves a critical role in the modulation of immune response and regulation of cutaneous commensal bacteria. Complement is implicated in several inflammatory skin diseases including systemic lupus erythematosus, angioedema, pemphigus, bullous pemphigoid, and HS. A model of HS pathogenesis is proposed, integrating the role of commensal bacteria, cutaneous immune responses, and complement dysregulation. The role of complement in disease pathogenesis has led to the development of novel anticomplement agents and clinical trials investigating the efficacy of such treatments in HS.
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