邻苯二甲酰亚胺
环加成
催化作用
化学
组合化学
药物化学
有机化学
邻苯二甲酰亚胺
作者
Chengxian Hu,Lu Wang,Yuanyuan Wu,Yonglong Zheng,Ying Fu,Zhengyin Du
摘要
A novel Pd-catalyzed assembly of N-substituted phthalimides by merging of [4+1] cycloaddition and difluorocarbene transfer carbonylation from 2-iodo-N-phenylbenzamides and difluorocarbene precursors is disclosed. Difluorocarbene acts as a carbonyl source and simultaneously forms one C-C bond, one C-N bond and one CO bond to produce N-substituted phthalimides in high yields.
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