阿兹平
化学
等甾体
戒指(化学)
立体化学
组合化学
喹诺酮类
有机化学
抗生素
生物化学
作者
Loïc Herter,Timothé Perrin,Thomas C. Fessard,Christophe Salomé
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-08-13
卷期号:25 (33): 6161-6166
标识
DOI:10.1021/acs.orglett.3c02250
摘要
The replacement of the aromatic ring in bioactive compounds with saturated bioisosteres has become a popular tactic to obtain novel structures with improved physicochemical profiles. In this paper, we describe an efficient synthesis of 3,5-methanobenzo[b]azepine analogues and suggest them as isosteres of quinolones. Quinolones are heteroaromatic, flat rings and considered as privileged scaffolds. An isosteric version of this scaffold with more 3D character would offer new options to expand their use.
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