沙门氏菌
粘菌素
质粒
MCR-1型
微生物学
生物
氨苄西林
四环素
抗生素耐药性
抗药性
基因
肠杆菌科
抗生素
遗传学
大肠杆菌
细菌
作者
Miaomiao Jia,Ping Li,Junyan Zhang,Zhongwen Chen,Lei Gao,Yiyong Sun,Xiaofei Zhang,Yan Ya,Guoying Zhu
出处
期刊:Foodborne Pathogens and Disease
[Mary Ann Liebert]
日期:2023-10-01
卷期号:20 (10): 467-476
标识
DOI:10.1089/fpd.2023.0051
摘要
Salmonella is a primary cause of foodborne diseases, and the increasing prevalence of mcr-1-carrying plasmids, which confer colistin resistance to Salmonella, poses significant global health concerns. As the frequency of occurrence of the mcr-1 gene is increasing globally, we studied the prevalence of mcr-1 in clinical Salmonella isolates by analyzing 195 clinical strains isolated in 2020. Of the 195 Salmonella isolates, 41 isolates were resistant to colistin. We found mcr-1 in two strains (Salmonella Typhimurium ZJJX20006 and Salmonella Kentucky ZJJX20014), which we analyzed in detail via whole-genome sequencing and antibiotic susceptibility testing. Two strains displayed resistance to ampicillin, ampicillin-sulbactam, tetracycline, chloramphenicol, and cotrimoxazole, while ZJJX20006 displayed resistance to colistin and ZJJX20014 was sensitive. Genomic analysis revealed that these strains had plasmid-encoded mcr-1 in IncHI2 plasmids, which were not similar to the mcr-1-IncX4 identified in 2016. These two strains also harbored other drug resistance genes, including blaOXA-1 and blaCTX-M-14. Our findings may help clarify the molecular mechanisms of mcr-1 dissemination among Salmonella strains in Jiaxing City and offer insights into the evolution of mcr-1 in Salmonella.
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