睑板腺
萎缩
人口
生物
内分泌学
内科学
分泌物
病理
医学
眼睑
环境卫生
外科
作者
Julie Wiedemann,Ghaidaa Kashgari,Shelley Lane,Brian C. Leonard,Kelly E. Knickelbein,Bogi Andersen,James V. Jester
标识
DOI:10.1016/j.jtos.2024.08.005
摘要
While meibomian gland dysfunction (MGD) is widely recognized as a major cause of evaporative dry eye disease, little is known about normal gland differentiation and lipid synthesis or the mechanism underlying gland atrophy and abnormal lipid secretion. The purpose of this study was to use single-cell and spatial transcriptomics to probe changes in cell composition, differentiation, and gene expression associated with two murine models of MGD: age-related gland atrophy in wild-type mice and altered meibum quality in acyl-CoA wax alcohol acyltransferase 2 (Awat2) knockout (KO) mice.
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