医学
糖尿病性视网膜病变
视网膜病变
黄斑水肿
糖尿病
血管内皮生长因子
内皮功能障碍
血管通透性
水肿
视网膜中央静脉阻塞
视网膜
内科学
眼科
内分泌学
血管内皮生长因子受体
作者
Elsa Wilma Böhm,Francesco Buonfiglio,Christina A. Korb,Alice Dauth,Norbert Pfeiffer,Andrzej Bręborowicz,Adrian Gericke
出处
期刊:Thrombosis and Haemostasis
[Georg Thieme Verlag KG]
日期:2024-09-18
标识
DOI:10.1055/s-0044-1791232
摘要
Retinal vascular diseases, such as diabetic retinopathy or retinal vein occlusion, are common causes of severe vision loss. Central to the pathophysiology of these conditions are endothelial dysfunction, inflammation, capillary leakage, ischemia, and pathological neoangiogenesis. Capillary damage leads to leakage and the development of macular edema, which is associated with vision loss and requires complex treatment. Sulodexide, a glycosaminoglycan composed of heparan sulfate and dermatan sulfate with high oral bioavailability, exhibits several favorable pharmacologic properties, including antithrombotic, anti-inflammatory, and endothelium-protective effects. Additionally, treatment with sulodexide has been associated with the reduction of oxidative stress and decreased expression of angiogenic growth factors, such as vascular endothelial growth factor. This review aims to provide an overview of the pharmacological properties, mechanisms of action, and therapeutic effects of sulodexide. Furthermore, its potential for clinical application in venous and diabetic diseases, such as venous thromboembolism, chronic venous insufficiency, peripheral artery disease, or diabetic nephropathy, is summarized. We also present experimental and clinical studies evaluating the potential of sulodexide in ocular conditions and discuss its therapeutic implications for the treatment of retinal vascular diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI