Development and verification of a novel blood viscoelastic monitoring method based on reciprocating motion of magnetic bead

往复运动 粘弹性 有孔小珠 凝结 磁珠 材料科学 生物医学工程 血栓弹性成像 计算机科学 复合材料 医学 色谱法 化学 人工智能 精神科 方位(导航)
作者
Xinyu Du,Fupan Chen,Lijin Gan,Yong Liu,Yu Zheng,Linghua Xing,Qi Zhou
出处
期刊:Biomedizinische Technik [De Gruyter]
卷期号:68 (2): 211-223
标识
DOI:10.1515/bmt-2022-0225
摘要

Blood coagulation function is an essential index in clinical examination, and it is of great significance to evaluate blood coagulation function comprehensively. Based on the blood viscoelasticity theory and hydrodynamics, we proposed a method to monitor the whole blood coagulation process based on the reciprocating motion of the magnetic bead (magnetic bead method for short). We have established a mathematical model between the moment acting on the magnetic bead and the viscoelasticity of blood in the process of blood coagulation. The change of blood viscoelasticity acks on the magnetic bead in the form of moment changes, which shows that the amplitude of the motion of the magnetic bead varies with the change of blood viscoelasticity. Designed and verified a blood coagulation monitoring device based on the reciprocating movement of the magnetic bead and discussed the device's parameters through the orthogonal experiment. Lastly, the TEG5000 was used as the control group to test the thromboelasticity of four groups of thromboelastography quality control products in the same batch and 10 groups of human whole blood. It verified that our device has good repeatability, and has good consistency with TEG5000, it has particular application potential as a new blood coagulation monitoring method.
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