生物
效应器
细胞生物学
功能(生物学)
免疫学
细胞
白细胞介素12
细胞毒性T细胞
遗传学
体外
作者
Tommaso Torcellan,Chr. Friedrich,Rémi Doucet-Ladevèze,Thomas Ossner,Virgínia Visaconill Solé,Sofie Riedmann,Milas Ugur,Fabian Imdahl,Stephan P. Rosshart,Sebastian J. Arnold,Mercedes Gomez de Agüero,Nicola Gagliani,Richard A. Flavell,Simone Backes,Wolfgang Kastenmüller,Georg Gasteiger
出处
期刊:Immunity
[Elsevier]
日期:2024-01-01
卷期号:57 (1): 124-140.e7
被引量:11
标识
DOI:10.1016/j.immuni.2023.11.018
摘要
Natural killer (NK) cells are present in the circulation and can also be found residing in tissues, and these populations exhibit distinct developmental requirements and are thought to differ in terms of ontogeny. Here, we investigate whether circulating conventional NK (cNK) cells can develop into long-lived tissue-resident NK (trNK) cells following acute infections. We found that viral and bacterial infections of the skin triggered the recruitment of cNK cells and their differentiation into Tcf1hiCD69hi trNK cells that share transcriptional similarity with CD56brightTCF1hi NK cells in human tissues. Skin trNK cells arose from interferon (IFN)-γ-producing effector cells and required restricted expression of the transcriptional regulator Blimp1 to optimize Tcf1-dependent trNK cell formation. Upon secondary infection, trNK cells rapidly gained effector function and mediated an accelerated NK cell response. Thus, cNK cells redistribute and permanently position at sites of previous infection via a mechanism promoting tissue residency that is distinct from Hobit-dependent developmental paths of NK cells and ILC1 seeding tissues during ontogeny.
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