化学
荧光
合理设计
生命系统
硒
纳米技术
人类健康
跟踪(心理语言学)
计算生物学
生化工程
计算机科学
生物
人工智能
有机化学
材料科学
物理
量子力学
医学
语言学
哲学
环境卫生
工程类
作者
Junping Wang,Mingkai Chen,Zhongyang Zhang,Li Ma,Tianfeng Chen
标识
DOI:10.1016/j.ccr.2023.215278
摘要
Selenium (Se) is of fundamental importance to human health as an essential trace element, mainly through regulation of selenoproteins (SePs). Therefore, monitoring Se transformation in living systems and revealing cellular functions of SePs are of great significance for diverse disease treatment. However, the lack of probing tools for in situ monitoring of Se species severely hinders its development in bio-analysis. Thus, the discovery of fluorescent probes with specific recognition and responses to SePs/Se-containing species are promising for investigating the biological actions of Se. Herein, we summarized the chemical properties of various active Se species and discussed the rational design of basic structures of fluorescent probes for Se species and their biomedical applications. We also highlighted the key findings on fluorescent probes for Se species inside living systems, and proposed a network for rational design and biomedical applications of fluorescent probes for biological Se-containing substances.
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