卡巴齐塔塞尔
表征(材料科学)
比例(比率)
化学
组合化学
纳米技术
材料科学
物理
医学
前列腺癌
雄激素剥夺疗法
癌症
量子力学
内科学
作者
Amarendhar Manda,Shravan Kumar Komati,Debjit Basu,Gopal Chandru Senadi,Arthanareeswari Maruthapillai,Rakeshwar Bandichhor
标识
DOI:10.1021/acs.oprd.4c00414
摘要
Cabazitaxel 1 is an antineoplastic agent belonging to the taxane class and approved for the treatment of hormone-refractory prostate cancer. During the optimization process of cabazitaxel, six related substances were detected using the gradient high-performance liquid chromatography technique. A thorough study was undertaken to identify, prepare, and control these six related substances. The molecular weights were determined by liquid chromatography–mass spectrometry analysis. Using spectroscopic analysis (high-resolution mass spectrometry (HRMS), infrared (IR), and NMR), the structures were determined as an amino alcohol derivative (CRS-1), 7,10-dimethoxy-10-deacetylbaccatin III (CRS-2), an N-formyl-related substance (CRS-3), 7,10,13-trimethoxy-10-deacetylbaccatin III (CRS-4), a DiBOC-related substance (CRS-5), and a process-related intermediate (CRS-6). The mechanistic aspects of the formation, synthesis, and control strategy of the associated substances were examined in detail.
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