Low-Consumption and High-Efficiency Isotope Analysis by Microultrasonic Single-Droplet Nebulization Sampling Multicollector Inductively Coupled Plasma Mass Spectrometry

Metal stable isotopes are increasingly applied in various fields, including planetary science and medical research, highlighting the need for isotope analysis methods capable of handling precious and microvolume samples. This study introduces a novel, low-consumption, high-efficiency isotope analysis method using MC-ICP-MS based on microultrasonic single-droplet nebulization (MUSDN). The proposed MUSDN enables the complete nebulization of microliter-sized droplets, delivering high-sensitivity transient analytical signals with a duration of several seconds. Under optimized conditions, MUSDN exhibited significantly enhanced sensitivity compared to conventional pneumatic nebulization, achieving 17-fold and 12-fold improvements for