The association of glutamic acid and gamma aminobdtyric acid with severity of Parkinson disease

Objective To explore the association of Glutamic acid (Glu) and gamma aminobdtyric acid with severity of Parkinson disease (PD) . Methods 45 cases with PDwere recruited to be trial group. 43 healthy persons were recruited to be control group. Glu and GABA of two groups were detected. Unified PD rating scale (UPDRS) and H-Y level were used to evaluate the severity of control group. Difference of Glu and GABA between two groups was analyzed. The association of Glu and GABA with severity of trial group was evaluated. Results Glu and GABA of trial group were higher than control group (P<0.01) . The association of Glu and GABA with severity of trial group was negative. Conclusion Glu and GABA of PD patients are increas and reflect the severity of patients. Key words: Glutamic acid; Gamma aminobdtyric acid; Parkinson disease