A randomized controlled trial of radiofrequency ablation and surgical resection in the treatment of small hepatocellular carcinoma

医学 肝细胞癌 射频消融术 经皮 存活率 经皮乙醇注射 随机对照试验 胃肠病学 相对风险 外科 内科学 总体生存率 烧蚀 置信区间
作者
Kai Feng,Jun Yan,Xiaowu Li,Feng Xia,Kuansheng Ma,Shuguang Wang,Ping Bie,Jiahong Dong
出处
期刊:Journal of Hepatology [Elsevier BV]
卷期号:57 (4): 794-802 被引量:700
标识
DOI:10.1016/j.jhep.2012.05.007
摘要

The aim of this study was to compare the efficacy of radiofrequency ablation (RFA) with surgical resection (RES) in the treatment of small hepatocellular carcinoma (HCC).A total of 168 patients with small HCC with nodular diameters of less than 4 cm and up to two nodules were randomly divided into RES (n=84) and RFA groups (n=84). Outcomes were carefully monitored and evaluated during the 3-year follow-up period.The 1-, 2-, and 3-year survival rates for the RES and RFA groups were 96.0%, 87.6%, 74.8% and 93.1%, 83.1%, 67.2%, respectively. The corresponding recurrence-free survival rates for the two groups were 90.6%, 76.7%, 61.1% and 86.2%, 66.6%, 49.6%, respectively. There were no statistically significant differences between the two groups in overall survival rate (p=0.342) or recurrence-free survival rate (p=0.122). Multivariate analysis demonstrated that the independent risk factors associated with survival were multiple occurrences of tumors at different hepatic locations (relative risk of 2.696; 95% CI: 1.189-6.117; p=0.018) and preoperative indocyanine green retention rate at 15 min (ICG-15) (relative risk of 3.853; 95% CI: 1.647-9.015; p=0.002).In patients with small hepatocellular carcinomas, percutaneous RFA may provide therapeutic effects similar to those of RES. However, percutaneous RFA is more likely to be incomplete for the treatment of small HCCs located at specific sites of the liver, and open or laparoscopic surgery may be the better choice.
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