氢吗啡酮
(+)-纳洛酮
类阿片
阿片类拮抗剂
麻醉剂拮抗剂
心理学
吗啡
敌手
美沙酮
兴奋剂
麻醉
医学
药理学
内科学
受体
作者
Alison Oliveto,Marc I. Rosen,Therese A. Kosten,Faiq A. Hameedi,Scott W. Woods,Thomas R. Kosten
标识
DOI:10.1037//1064-1297.6.2.169
摘要
Naloxone-hydromorphone combinations were tested in participants trained to discriminate naloxone from placebo under a novel-response drug discrimination procedure while maintained on methadone. Naloxone alone produced dose-related increases in naloxone-appropriate responding, little or no "novel"-appropriate responding, and increases in opioid antagonist adjective ratings (n = 5). Hydromorphone alone produced dose-related increases in novel-appropriate responding, little or no naloxone-appropriate responding, and increases in opioid agonist adjective ratings (n = 6). When combined with naloxone, hydromorphone produced dose-related decreases in naloxone-appropriate responding and antagonist adjective ratings (n = 6). These findings are consistent with nonhuman data and suggest that this procedure may be useful as a human laboratory model of opioid withdrawal.
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