假基因
生物
基因组
转座因子
细菌基因组大小
遗传学
普氏立克次体
DNA
细胞内寄生虫
基因组进化
细菌
基因
立克次体
病毒
作者
Jeffrey G. Lawrence,Roger W. Hendrix,Sherwood Casjens
标识
DOI:10.1016/s0966-842x(01)02198-9
摘要
Most bacterial genomes have very few pseudogenes; notable exceptions include the genomes of the intracellular parasites Rickettsia prowazekii and Mycobacterium leprae. As DNA can be introduced into microbial genomes in many ways, the compact nature of these genomes suggests that the rate of DNA influx is balanced by the rate of DNA deletion. We propose that the influx of dangerous genetic elements such as transposons and bacteriophages selects for the maintenance of relatively high deletion rates in most bacteria; the sheltered lifestyle of intracellular parasites removes this threat, leading to reduced deletion rates and larger pseudogene loads.
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