Efficient Enantioselective Synthesis of Optically Active Diols by Asymmetric Hydrogenation with Modular Chiral Metal Catalysts

Angewandte Chemie International EditionVolume 48, Issue 41 p. 7556-7559 Communication Efficient Enantioselective Synthesis of Optically Active Diols by Asymmetric Hydrogenation with Modular Chiral Metal Catalysts† Renat Kadyrov Dr., Renat Kadyrov Dr. [email protected] Evonik Degussa GmbH, Rodenbacher Chaussee 4, 63457 Hanau-Wolfgang (Germany)Search for more papers by this authorRené M. Koenigs Dipl.-Chem., René M. Koenigs Dipl.-Chem. RWTH Aachen University, Institute of Organic Chemistry, Landoltweg 1, 52074 Aachen (Germany)Search for more papers by this authorClaus Brinkmann Dipl.-Chem., Claus Brinkmann Dipl.-Chem. RWTH Aachen University, Institute of Organic Chemistry, Landoltweg 1, 52074 Aachen (Germany)Search for more papers by this authorDavid Voigtlaender Dr., David Voigtlaender Dr. Evonik Degussa GmbH, Rodenbacher Chaussee 4, 63457 Hanau-Wolfgang (Germany)Search for more papers by this authorMagnus Rueping Prof. Dr., Magnus Rueping Prof. Dr. [email protected] RWTH Aachen University, Institute of Organic Chemistry, Landoltweg 1, 52074 Aachen (Germany)Search for more papers by this author Renat Kadyrov Dr., Renat Kadyrov Dr. [email protected] Evonik Degussa GmbH, Rodenbacher Chaussee 4, 63457 Hanau-Wolfgang (Germany)Search for more papers by this authorRené M. Koenigs Dipl.-Chem., René M. Koenigs Dipl.-Chem. RWTH Aachen University, Institute of Organic Chemistry, Landoltweg 1, 52074 Aachen (Germany)Search for more papers by this authorClaus Brinkmann Dipl.-Chem., Claus Brinkmann Dipl.-Chem. RWTH Aachen University, Institute of Organic Chemistry, Landoltweg 1, 52074 Aachen (Germany)Search for more papers by this authorDavid Voigtlaender Dr., David Voigtlaender Dr. Evonik Degussa GmbH, Rodenbacher Chaussee 4, 63457 Hanau-Wolfgang (Germany)Search for more papers by this authorMagnus Rueping Prof. Dr., Magnus Rueping Prof. Dr. [email protected] RWTH Aachen University, Institute of Organic Chemistry, Landoltweg 1, 52074 Aachen (Germany)Search for more papers by this author First published: 23 September 2009 https://doi.org/10.1002/anie.200902835Citations: 45 † We thank Evonik Degussa for financial support, the Fonds der chemischen Industrie for a stipend to R.M.K., and Dr. Juan Almena and Gerd Geiss for technical assistance. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract Valuable vicinal 1,2-diols can be prepared with high enantioselectivity by the asymmetric ruthenium-catalyzed hydrogenation of aryl- and alkyl-substituted α-hydroxy ketones (see scheme). The ligands, which are distinguished by their modular construction, display excellent enantioface differentiation. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_200902835_sm_miscellaneous_information.pdf131.2 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume48, Issue41September 28, 2009Pages 7556-7559 RelatedInformation