In this paper we examine some general features of the time-dependent dynamics of drop deformation and breakup at low Reynolds numbers. The first aspect of our study is a detailed numerical investigation of the ‘end-pinching’ behaviour reported in a previous experimental study. The numerics illustrate the effects of viscosity ratio and initial drop shape on the relaxation and/or breakup of highly elongated droplets in an otherwise quiescent fluid. In addition, the numerical procedure is used to study the simultaneous development of capillary-wave instabilities at the fluid-fluid interface of a very long, cylindrically shaped droplet with bulbous ends. Initially small disturbances evolve to finite amplitude and produce very regular drop breakup. The formation of satellite droplets, a nonlinear phenomenon, is also observed.