Fasting alleviates bleomycin-induced lung inflammation and fibrosis via decreased Tregs and monocytes

医学 博莱霉素 炎症 纤维化 肺纤维化 肺纤维化 免疫学 内科学 癌症研究 化疗
作者
NULL AUTHOR_ID,NULL AUTHOR_ID,Qi Zhang,X. Chen,Wenting Liang,Yanling Zheng,NULL AUTHOR_ID,Yue Liao,Cheng Fu,NULL AUTHOR_ID,Xiaomin Li,Yu Zheng,NULL AUTHOR_ID,Erxia Shen
出处
期刊:Advances in Medical Sciences [Elsevier]
卷期号:69 (2): 303-311 被引量:2
标识
DOI:10.1016/j.advms.2024.07.004
摘要

Idiopathic pulmonary fibrosis (IPF), a chronic and progressively worsening condition characterized by interstitial lung inflammation and fibrosis of unknown etiology, has a grim prognosis. The treatment options for IPF are limited and new therapeutic strategies are urgently needed. Dietary restriction can improve various inflammatory diseases, but its therapeutic effect on bleomycin (BLM)-induced pulmonary fibrosis mouse model remains unclear. This study aims to investigate whether intermittent fasting (IF) can alleviate BLM-induced pulmonary inflammation and fibrosis. Pulmonary fibrosis mouse models were induced by BLM. The IF group underwent 24-hour fasting cycles for one week prior and three weeks following BLM administration. Meanwhile, the ad libitum feeding group had unrestricted access to food throughout the experiment. The evaluation focused on lung pathology via histological staining, qPCR analysis of collagen markers, and immune cell profiling through flow cytometry. IF group significantly reduced inflammation and fibrosis in lung tissues of BLM-induced mice compared to ad libitum feeding group. qPCR results showed IF remarkably decreased the mRNA expression of Col 1a and Col 3a in the lungs of BLM-induced mouse models. IF also reduced the numbers of regulatory T cells (Tregs), T helper 17 (Th17) cells, monocytes, and monocyte-derived alveolar macrophages (MoAMs) in the lung tissues. IF may improve BLM-induced pulmonary fibrosis by decreasing numbers of immune cells including Treg cells, Th17 cells, monocytes, and MoAMs in the lungs. This study offers experimental validation for dietary intervention as a viable treatment modality in IPF management.
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