Fermented soybean foods (natto) ameliorate age-related cognitive decline by hippocampal TAAR1-mediated activation of the CaMKII/CREB/BDNF signaling pathway in senescence-accelerated mouse prone 8 (SAMP8)

Natto is a traditional fermented soybean-based food that has been an integral part of Japanese cuisine. This study demonstrated that the oral administering natto ameliorated cognitive decline by activating TAAR1-mediated CaMKII/CREB/BDNF signaling pathway in the hippocampus of SAMP8 mice.