Residential greenness and incident idiopathic pulmonary fibrosis: A prospective study

医学 特发性肺纤维化 四分位间距 前瞻性队列研究 比例危险模型 内科学 人口学 社会学
作者
Linxi Tang,Fei-Peng Cui,Yudiyang Ma,Dankang Li,Jianing Wang,Run Liu,Yaohua Tian
出处
期刊:Environmental Research [Elsevier]
卷期号:245: 117984-117984 被引量:1
标识
DOI:10.1016/j.envres.2023.117984
摘要

The impact of residential greenness on incident idiopathic pulmonary fibrosis (IPF) is unknown. We aimed to assess the association between residential greenness and incident IPF, identify underlying pathways, and further evaluate the effect among different genetic subgroups. 469,348 participants in the UK Biobank were included and followed until December 2020. Normalized difference vegetation index (NDVI) within 300-, 500-, 1000-, and 1500-m buffers (NDVI300m, NDVI500m, NDVI1000m, and NDVI1500m) were employed as indicators of greenness. The polygenic risk score (PRS) was constructed based on 13 independent SNPs. Cox models were fitted to assess the association of residential greenness with incident IPF. Casual mediation analyses were applied to evaluate potential mediators. After a median follow-up of 11.85 years, 1574 IPF cases were identified. We found residential greenness inversely associated with incident IPF. The HRs (95%CIs) for each interquartile increase of NDVI300m, NDVI500m, NDVI1000m, NDVI1500m were 0.93 (0.87, 0.99), 0.92 (0.86, 0.98), 0.89 (0.83, 0.95), and 0.89 (0.83, 0.95), respectively. The association was stronger among individuals with intermediate or high genetic risk. In mediation analyses, the main mediators identified were PM2.5 and NO2, with proportion mediated estimated to be 31.92% and 40.61% respectively for NDVI300m. Residential greenness was associated with reduced risk of incident IPF.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
科研通AI2S应助灯火入眉弯采纳,获得10
1秒前
印染完成签到,获得积分10
1秒前
Oz完成签到,获得积分10
3秒前
kmtkmtkk完成签到,获得积分10
4秒前
mhr完成签到,获得积分20
5秒前
6秒前
酷波er应助机智的含蕾采纳,获得10
10秒前
潇洒的如松完成签到,获得积分10
11秒前
飞天猫完成签到,获得积分10
14秒前
松谦完成签到,获得积分20
14秒前
嗯嗯嗯完成签到 ,获得积分10
17秒前
17秒前
圆圆的分子球完成签到 ,获得积分10
18秒前
21秒前
22秒前
西瓜完成签到 ,获得积分10
29秒前
fifteen发布了新的文献求助10
30秒前
香蕉觅云应助墨竹采纳,获得10
30秒前
kuo发布了新的文献求助10
33秒前
34秒前
carrie完成签到,获得积分10
36秒前
潇洒哥发布了新的文献求助10
36秒前
FashionBoy应助阔达的曼凡采纳,获得10
36秒前
39秒前
田様应助歪哔巴布采纳,获得10
41秒前
标致冬日完成签到,获得积分10
44秒前
45秒前
XS123发布了新的文献求助10
45秒前
叶知秋完成签到,获得积分10
45秒前
桐桐应助雯雯采纳,获得10
46秒前
完美世界应助活泼学生采纳,获得10
48秒前
luchen发布了新的文献求助10
49秒前
49秒前
sam完成签到,获得积分20
49秒前
饱满翠绿完成签到,获得积分10
50秒前
sdysdbd发布了新的文献求助30
50秒前
51秒前
纪复天完成签到,获得积分10
52秒前
歪哔巴布发布了新的文献求助10
56秒前
adam完成签到,获得积分10
56秒前
高分求助中
The Oxford Handbook of Social Cognition (Second Edition, 2024) 1050
Kinetics of the Esterification Between 2-[(4-hydroxybutoxy)carbonyl] Benzoic Acid with 1,4-Butanediol: Tetrabutyl Orthotitanate as Catalyst 1000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
Chen Hansheng: China’s Last Romantic Revolutionary 500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3140361
求助须知:如何正确求助?哪些是违规求助? 2791116
关于积分的说明 7798129
捐赠科研通 2447583
什么是DOI,文献DOI怎么找? 1301980
科研通“疑难数据库(出版商)”最低求助积分说明 626354
版权声明 601194