Metabolic syndrome and the progression of knee osteoarthritis on MRI

医学 骨关节炎 磁共振成像 软骨 内科学 舱室(船) 代谢综合征 腰围 体质指数 病理 放射科 肥胖 解剖 海洋学 地质学 替代医学
作者
Nuria E J Jansen,Eveline Molendijk,D. Schiphof,Joyce B. J. van Meurs,Edwin H. G. Oei,Marienke van Middelkoop,Sita Bierma‐Zeinstra
出处
期刊:Osteoarthritis and Cartilage [Elsevier]
卷期号:31 (5): 647-655 被引量:13
标识
DOI:10.1016/j.joca.2023.02.003
摘要

ObjectiveMetabolic osteoarthritis (OA) is one of the proposed clinical phenotypes defined by the existence of metabolic syndrome (MetS). This study aimed to (1) investigate whether MetS and its components are associated with progression of knee OA magnetic resonance imaging (MRI) features, and (2) to evaluate the interaction of MetS with menopause and progression of MRI features.Method682 women from the Rotterdam Study who participated in a sub-study with knee MRI data available and 5-year follow-up were included. Tibiofemoral (TF) and patellofemoral (PF) OA features were assessed with the MRI Osteoarthritis Knee Score. MetS was quantified by the MetS severity Z-score. Generalized estimating equations were used to evaluate associations between MetS and menopausal transition and progression of MRI features.ResultsMetS severity at baseline was associated with progression of osteophytes in all compartments, bone marrow lesions (BMLs) in the PF compartment, and cartilage defects in the medial TF compartment. Waist circumference was associated with progression of osteophytes in all compartments and cartilage defects in the medial TF compartment. High-density lipoprotein (HDL)-cholesterol levels were associated with progression of osteophytes in the medial and lateral TF compartment and glucose levels with osteophytes in the PF and medial TF compartment. No interactions were found between MetS with menopausal transition and MRI features.ConclusionWomen with higher MetS severity at baseline showed progression of osteophytes, BMLs, and cartilage defects, indicating more structural knee OA progression after 5 years. Further studies are required to understand whether targeting MetS components may prevent the progression of structural knee OA in women.
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