纳米载体
巨噬细胞
脂质体
药物输送
巨噬细胞极化
癌症研究
靶向给药
细胞
免疫系统
化学
细胞生物学
医学
生物
免疫学
生物化学
体外
有机化学
作者
Daniel Mendanha,Joao Vieira De Castro,Marta R. Casanova,Sara Gimondi,Helena Ferreira,Nuno M. Neves
标识
DOI:10.1016/j.nano.2023.102663
摘要
Glioblastoma (GBM) is a highly aggressive malignant brain tumor currently without an effective treatment. Inspired by the recent advances in cell membrane biomimetic nanocarriers and by the key role of macrophages in GBM pathology, we developed macrophage membrane liposomes (MML) for GBM targeting. For the first time, it was assessed the role of macrophage polarization states in the effectiveness of these drug delivery systems. Interestingly, we observed that MML derived from M2 macrophages (M2 MML) presents higher uptake and increased delivery of the anticarcinogenic drug doxorubicin compared to M1 macrophage-derived nanocarriers (M1 MML) and control liposomes (CL). Moreover, the lowest uptake by macrophages of MML reveals promising immune escaping properties. Notably, M2 macrophages unveiled a higher expression of integrin CD49d, a crucial protein involved in the bilateral communication of macrophages with tumor cells. Therefore, our findings suggest the potential of using M2 macrophage membranes to develop novel nanocarriers targeting GBM.
科研通智能强力驱动
Strongly Powered by AbleSci AI