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Associations between nephron number and podometrics in human kidneys

足细胞 肾小球硬化 肾单位 体视学 肾小球 肾脏疾病 局灶节段性肾小球硬化 肾小球 突触素 内科学 病理 肾小球肾炎 生物 内分泌学 医学 蛋白尿
作者
Kotaro Haruhara,Go Kanzaki,Takaya Sasaki,Saeko Hatanaka,Yusuke Okabayashi,Victor G. Puelles,Ian Harper,Akira Shimizu,Luise A. Cullen‐McEwen,Nobuyuki Tsuboi,Takashi Yokoo,John F. Bertram
出处
期刊:Kidney International [Elsevier]
卷期号:102 (5): 1127-1135 被引量:9
标识
DOI:10.1016/j.kint.2022.07.028
摘要

Podocyte loss and resultant nephron loss are common processes in the development of glomerulosclerosis and chronic kidney disease. While the cortical distribution of glomerulosclerosis is known to be non-uniform, the relationship between the numbers of non-sclerotic glomeruli (NSG), podometrics and zonal differences in podometrics remain incompletely understood. To help define this, we studied autopsy kidneys from 50 adults with median age 68 years and median eGFR 73.5 mL/min/1.73m2 without apparent glomerular disease in a cross-sectional analysis. The number of NSG per kidney was estimated using the physical dissector/fractionator combination, while podometrics were estimated using model-based stereology. The number of NSG per kidney was directly correlated with podocyte number per tuft and podocyte density. Each additional 100,000 NSG per kidney was associated with 26 more podocytes per glomerulus and 16 podocytes per 106 μm3 increase in podocyte density. These associations were independent of clinical factors and cortical zone. While podocyte number per glomerulus was similar in the three zones, superficial glomeruli were the smallest and had the highest podocyte density but smallest podocytes. Increasing age and hypertension were associated with lower podocyte number, with age mostly affecting superficial glomeruli, and hypertension mostly affecting juxtamedullary glomeruli. Thus, in this first study to report a direct correlation between the number of NSG and podometrics, we suggest that podocyte number is decreasing in NSG of individuals losing nephrons. However, another possible interpretation may be that more nephrons might protect against further podocyte loss.
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