薯蓣皂甙元
血管生成
心肌梗塞
心功能曲线
新生血管
医学
癌症研究
基因沉默
药理学
下调和上调
生物
内科学
心力衰竭
基因
生物化学
遗传学
作者
Xuehua Liu,Dong Shen,Longfei Liu,Altman Yuzhu Peng,Qiulun Lu
标识
DOI:10.1016/j.bbrc.2024.149941
摘要
While diosgenin has been demonstrated effective in various cardiovascular diseases, its specific impact on treating heart attacks remains unclear. Our research revealed that diosgenin significantly improved cardiac function in a myocardial infarction (MI) mouse model, reducing cardiac fibrosis and cell apoptosis while promoting angiogenesis. Mechanistically, diosgenin upregulated the Hand2 expression, promoting the proliferation and migration of endothelial cells under hypoxic conditions. Acting as a transcription factor, HAND2 activated the angiogenesis-related gene Aggf1. Conversely, silencing Hand2 inhibited the diosgenin-induced migration of hypoxic endothelial cells and angiogenesis. In summary, these findings provide new insights into the protective role of diosgenin in MI, validating its effect on angiogenic activity and providing a theoretical basis for clinical treatment strategies.
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