Tigecycline-Induced Acute Pancreatitis with Rechallenge: A Case Report

替加环素 医学 不利影响 胰腺炎 急性胰腺炎 抗生素 内科学 外科 微生物学 生物
作者
Charles De Mesa,Maria Aurora Dajoyag-Mejia,Regina Issac,Rabih O. Darouiche
出处
期刊:The Journal of pharmacy technology [SAGE]
卷期号:29 (1): 3-8 被引量:5
标识
DOI:10.1177/875512251302900102
摘要

Objective: To report a case of tigecycline-induced acute pancreatitis. Case Summary: A 50-year-old African American man with spinal cord injury was hospitalized on 2 occasions for recurrence of an infected pressure ulcer requiring systemic antibiotic therapy. Bone and tissue cultures from his initial hospitalization grew multidrug resistant (MDR) Acinetobacter baumanii sensitive to tigecycline. He was treated with intravenous tigecycline on these 2 occasions (50-mg infusions every 12 hours), each of which resulted in significant elevation in serum amylase (to 615 U/L and 715 U/L) and lipase (to 325 U/L and 616 U/L) levels. On each occasion, the pancreatic enzymes became normal after discontinuing tigecycline. Discussion: Tigecycline is the first FDA-approved drug in the class of antibiotics called glycylcyclines, which are developed from tetracyclines to afford broad coverage against certain resistant gram-positive and gramnegative bacteria. It is recommended for patients at least 18 years of age for treatment of complicated intraabdominal infections, community-acquired bacterial pneumonia and complicated skin and skin structure infections caused by susceptible organisms. Tigecycline-induced pancreatitis is a rare adverse event. Review of the literature yielded only 6 prior documented cases (5 adult and 1 pediatric cases). Although the pediatric case demonstrated rechallenge, the patient concurrently received other antibiotics that are known to cause pancreatitis. Conclusions: This is the first report, to our knowledge, of pancreatitis associated with monotherapy with tigecycline, and this relationship was confirmed upon rechallenging our patient with tigecycline. An objective causality assessment revealed that the adverse-drug-associated event was definite.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
QI发布了新的文献求助10
1秒前
YY完成签到 ,获得积分10
1秒前
gqp应助111111采纳,获得10
1秒前
整齐的大开应助无限猫咪采纳,获得10
2秒前
赘婿应助KD采纳,获得10
3秒前
hl7166发布了新的文献求助10
5秒前
5秒前
5秒前
5秒前
6秒前
7秒前
bkagyin应助ASOFCS采纳,获得10
9秒前
冯兴龙发布了新的文献求助10
10秒前
科研通AI2S应助xdf采纳,获得10
11秒前
ASOFCS完成签到,获得积分10
13秒前
程风破浪完成签到,获得积分10
17秒前
dd完成签到 ,获得积分10
18秒前
裘文献完成签到,获得积分10
18秒前
星辰大海应助KD采纳,获得10
18秒前
lucky完成签到,获得积分20
18秒前
勤奋思思完成签到 ,获得积分10
19秒前
19秒前
云瑾应助笑面客采纳,获得10
22秒前
songze完成签到,获得积分10
23秒前
聪仔应助虚幻馒头采纳,获得30
23秒前
23秒前
lvsehx完成签到,获得积分10
24秒前
卷卷发布了新的文献求助10
25秒前
井哥儿应助zhoujunyan采纳,获得80
26秒前
英俊的铭应助SS采纳,获得10
26秒前
26秒前
顾矜应助lvsehx采纳,获得10
27秒前
忧虑的羊完成签到,获得积分20
28秒前
bkagyin应助七七七采纳,获得10
30秒前
传奇3应助KD采纳,获得10
30秒前
30秒前
浩浩完成签到 ,获得积分10
31秒前
31秒前
ccboom完成签到,获得积分10
32秒前
云瑾应助Ericker采纳,获得10
32秒前
高分求助中
Medicina di laboratorio. Logica e patologia clinica 600
Sarcolestes leedsi Lydekker, an ankylosaurian dinosaur from the Middle Jurassic of England 500
《关于整治突出dupin问题的实施意见》(厅字〔2019〕52号) 500
Language injustice and social equity in EMI policies in China 500
mTOR signalling in RPGR-associated Retinitis Pigmentosa 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
Geochemistry, 2nd Edition 地球化学经典教科书第二版 401
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3213971
求助须知:如何正确求助?哪些是违规求助? 2862579
关于积分的说明 8134494
捐赠科研通 2528767
什么是DOI,文献DOI怎么找? 1363009
科研通“疑难数据库(出版商)”最低求助积分说明 643729
邀请新用户注册赠送积分活动 616070