In silicoandin vivoanalysis to identify the antidiabetic activity of beta sitosterol in adipose tissue of high fat diet and sucrose induced type-2 diabetic experimental rats

过剩4 脂肪组织 内分泌学 内科学 胰岛素受体 胰岛素 葡萄糖转运蛋白 2型糖尿病 甘油三酯 化学 糖尿病 胰岛素抵抗 体内 葡萄糖稳态 药理学 胆固醇 医学 生物 生物技术
作者
Ponnulakshmi Rajagopal,B. Shyamaladevi,P. Vijayalakshmi,Selvaraj Jayaraman
出处
期刊:Toxicology Mechanisms and Methods [Informa]
卷期号:29 (4): 276-290 被引量:178
标识
DOI:10.1080/15376516.2018.1545815
摘要

Adipose tissue is the primary site of storage for excess energy as triglyceride and it helps in synthesizing a number of biologically active compounds that regulate metabolic homeostasis. Consumption of high dietary fat increases stored fat mass and is considered as a main risk factor for metabolic diseases. Beta-sitosterol (β-sitosterol) is a plant sterol. It has the similar chemical structure like cholesterol. Clinical and experimental studies have shown that β-sitosterol has anti-diabetic, hypolipidemic, anti-cancer, anti-arthritic, and hepatoprotective role. However, effect of β-sitosterol on insulin signaling molecules and glucose oxidation has not been explored. Hence in the present study we aimed to discover the protective role of β-sitosterol on the expression of insulin signaling molecules in the adipose tissue of high-fat diet and sucrose-induced type-2 diabetic experimental rats. Effect dose of β-sitosterol (20 mg/kg b.wt, orally for 30 days) was given to high fat diet and sucrose-induced type-2 diabetic rats to study its anti-diabetic activity. Results of the study showed that the treatment with β-sitosterol to diabetes-induced rats normalized the altered levels of blood glucose, serum insulin and testosterone, lipid profile, oxidative stress markers, antioxidant enzymes, insulin receptor (IR), and glucose transporter 4 (GLUT4) proteins. Our present findings indicate that β-sitosterol improves glycemic control through activation of IR and GLUT4 in the adipose tissue of high fat and sucrose-induced type-2 diabetic rats. Insilico analysis also coincides with invivo results. Hence it is very clear that β-sitosterol can act as potent antidiabetic agent.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
顾矜应助steforeca采纳,获得30
3秒前
情怀应助yduan采纳,获得10
4秒前
luvian完成签到,获得积分10
4秒前
天润佳苑发布了新的文献求助10
5秒前
Beckyyy发布了新的文献求助10
5秒前
6秒前
7秒前
科研通AI2S应助哈哈同学采纳,获得10
7秒前
酷波er应助wanci采纳,获得30
7秒前
8秒前
9秒前
10秒前
luvian发布了新的文献求助20
10秒前
11秒前
zxk发布了新的文献求助10
12秒前
12秒前
科研搬运工完成签到,获得积分10
12秒前
特来骑发布了新的文献求助10
13秒前
14秒前
Epiphany发布了新的文献求助10
14秒前
小苏苏发布了新的文献求助30
14秒前
heart发布了新的文献求助10
15秒前
yduan发布了新的文献求助10
15秒前
NicholasZ完成签到,获得积分10
16秒前
双黄应助王九八采纳,获得10
17秒前
hzb完成签到 ,获得积分10
17秒前
唐同学发布了新的文献求助10
18秒前
隐形曼青应助文章多多采纳,获得10
19秒前
yan发布了新的文献求助10
20秒前
22秒前
科目三应助1111采纳,获得10
22秒前
NicholasZ发布了新的文献求助10
23秒前
25秒前
OK啊01发布了新的文献求助10
26秒前
嗯哼应助heart采纳,获得30
26秒前
27秒前
乐乐应助ruuuu采纳,获得10
29秒前
小花dgy完成签到,获得积分10
29秒前
特来骑完成签到,获得积分10
30秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Very-high-order BVD Schemes Using β-variable THINC Method 830
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3248513
求助须知:如何正确求助?哪些是违规求助? 2891903
关于积分的说明 8269128
捐赠科研通 2559920
什么是DOI,文献DOI怎么找? 1388768
科研通“疑难数据库(出版商)”最低求助积分说明 650897
邀请新用户注册赠送积分活动 627798