Me3N-promoted synthesis of 2,3,4,4a-tetrahydroxanthen-1-one: preparation of thiosemicarbazone derivatives, their solid state self-assembly and antimicrobial properties

Thiosemicarbazones (5a–5j) have been synthesized from 2,3,4,4a-tetrahydroxanthen-1-one, obtained in high yield through Me₃N-promoted domino Baylis–Hillman/oxa-Michael reaction. Their solid-state self-assembly and antimicrobial properties are studied.