酪蛋白激酶2
生物
磷酸化
酪蛋白激酶1
蛋白激酶A
细胞生物学
DNA损伤
激酶
染色质
地图2K7
细胞周期蛋白依赖激酶2
生物化学
DNA
作者
David M. Keller,Xuan Zeng,Li Wang,Q H Zhang,M. Kapoor,Haidong Shu,Richard H. Goodman,Guillermina Lozano,Yingming Zhao,Haojie Lu
出处
期刊:Molecular Cell
[Elsevier]
日期:2001-02-01
卷期号:7 (2): 283-292
被引量:291
标识
DOI:10.1016/s1097-2765(01)00176-9
摘要
Phosphorylation of the human p53 protein at Ser-392 has been shown to be responsive to UV but not gamma irradiation. Here we describe identification and purification of a mammalian UV-activated protein kinase complex that phosphorylates Ser-392 of p53 in vitro. This kinase complex contains casein kinase 2 (CK2) and the chromatin transcriptional elongation factor FACT (a heterodimer of hSpt16 and SSRP1). In vitro studies show that FACT alters the specificity of CK2 in the complex such that it selectively phosphorylates p53 over other substrates including casein. In addition, phosphorylation by the kinase complex enhances p53 activity. These results thus provide a potential mechanism for p53 activation by UV irradiation.
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