断点
T细胞受体
染色体易位
生物
T细胞
受体
细胞
V(D)J复合
重组
遗传学
分子生物学
癌症研究
细胞生物学
基因
免疫系统
作者
N S D Larmonie,W. A. Dik,Jules P.P. Meijerink,Irene Homminga,Jacques J. M. van Dongen,Anton W. Langerak
出处
期刊:Haematologica
[Ferrata Storti Foundation]
日期:2013-07-31
卷期号:98 (8): 1173-1184
被引量:33
标识
DOI:10.3324/haematol.2012.082156
摘要
Aberrant recombination between T-cell receptor genes and oncogenes gives rise to chromosomal translocations that are genetic hallmarks in several subsets of human T-cell acute lymphoblastic leukemias. The V(D)J recombination machinery has been shown to play a role in the formation of these T-cell receptor translocations. Other, non-T-cell receptor chromosomal aberrations, such as SIL-TAL1 deletions, have likewise been recognized as V(D)J recombination associated aberrations. Despite the postulated role of V(D)J recombination, the extent of the V(D)J recombination machinery involvement in the formation of T-cell receptor and non-T-cell receptor aberrations in T-cell acute lymphoblastic leukemia is still poorly understood. We performed a comprehensive in silico and ex vivo evaluation of 117 breakpoint sites from 22 different T-cell receptor translocation partners as well as 118 breakpoint sites from non-T-cell receptor chromosomal aberrations. Based on this extensive set of breakpoint data, we provide a comprehensive overview of T-cell receptor and oncogene involvement in T-ALL. Moreover, we assessed the role of the V(D)J recombination machinery in the formation of chromosomal aberrations, and propose an up-dated mechanistic classification on how the V(D)J recombination machinery contributes to the formation of T-cell receptor and non-T-cell receptor aberrations in human T-cell acute lymphoblastic leukemia.
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