细胞生物学
跨膜蛋白
再生(生物学)
化学
脊髓损伤
脊髓
整合素
肽
生物物理学
受体
脚手架
神经科学
生物
生物化学
医学
生物医学工程
作者
Zaida Álvarez,Alexandra N. Edelbrock,Ivan R. Sasselli,Juan A. Ortega,Ruomeng Qiu,Zois Syrgiannis,Peter A. Mirau,F. Chen,Stacey M. Chin,Steven Weigand,Evangelos Kiskinis,Samuel I. Stupp
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2021-11-12
卷期号:374 (6569): 848-856
被引量:199
标识
DOI:10.1126/science.abh3602
摘要
Fibril motion improves peptide signaling Artificial scaffolds that bear the peptide-signaling sequences of proteins for tissue regeneration often have limited effectiveness. Álvarez et al . synthesized supramolecular peptide fibril scaffolds bearing two peptide sequences that promote nerve regeneration, one that reduces glial scarring and another that promotes blood vessel formation (see the Perspective by Wojciechowski and Stevens). In a mouse model of paralyzing human spinal cord injury, mutations in a tetrapeptide domain outside of the signaling regions improved recovery by promoting intense supramolecular motion within the fibrils. The mutation with the most intense dynamics resulted in corticospinal axon regrowth and myelination, functional revascularization, and motor neuron survival. —PDS
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