良性阵发性位置性眩晕
医学
生物标志物
发病机制
内科学
维生素
胃肠病学
内耳
眩晕
维生素D与神经学
内分泌学
外科
解剖
化学
生物化学
作者
Harsha Yadav,DVK Irugu,Lakshmy Ramakrishanan,Archana Singh,Ransi Ann Abraham,Kapil Sikka,Lokesh Kumar Penubarthi,Hitesh Verma
出处
期刊:Journal of vestibular research
[IOS Press]
日期:2021-10-16
卷期号:31 (6): 433-440
被引量:6
摘要
Serum otolin-1 is an inner ear protein exclusively expressed in otoconia and cells of vestibule and cochlea. Serum otolin-1 is found to be quantifiable in patients with BPPV. Low Vitamin-D is associated with pathogenesis of BPPV. Since otoconia degeneration contributes to BPPV, lack of Vitamin-D may impact otoconia structure and integrity.We aimed at studying the s.otolin-1 as biomarker and significance of vit-D in BPPV.23 patients in test and control groups respectively were chosen within the age of 20 to 65 years. All the patients were diagnosed using Dix Hallpike menouver and head roll test, patients were treated with appropriate Canal Reposition Menouver (CRM).Serum Otolin-1 levels among the test ranged from 366 to 882 pg/mL with mean of 585.17 pg/mL whereas in control group ranged from 223 to 462 pg/mL with mean of 335.26 pg/mL. Mean Vitamin-D levels among the test group was 22.67 ng/mL (Range = 6.3-68.4) and that of control 15.43 pg/mL (Range = 5.4-27.7) respectively. The relationship between the serum Otolin-1 and Vitamin-D was not statistically significant.Otolin-1 levels is increased in BPPV patients and is sensitive in BPPV, specificity needs to be validated. Role of vitamin-D with respect to inner ear proteins needs further investigation.
科研通智能强力驱动
Strongly Powered by AbleSci AI