石英晶体微天平
生物传感器
微电子机械系统
小型化
材料科学
谐振器
石英
检出限
微通道
光电子学
化学
分析化学(期刊)
纳米技术
色谱法
吸附
复合材料
有机化学
作者
Lianjie Zhou,Fumihito Kato,Hirotsugu Ogi
标识
DOI:10.35848/1347-4065/abea50
摘要
Abstract We present a wireless quartz crystal microbalance (QCM) biosensor fabricated using MEMS technology. The MEMS QCM biosensor contains a 125 MHz AT-cut quartz resonator embedded in the microchannel. Because of the compact design, the MEMS QCM biosensor is suitable for mass production and device miniaturization. We performed immunoglobulin G (IgG) detection measurements with different concentrations of IgG. The detection limit was 1 ng ml –1 or less, which is superior to that of the gold-standard surface plasma resonance method. Furthermore, we studied the binding affinity between protein A and IgG by studying the frequency response of the QCM biosensor. We found good agreement with reported values. Therefore, the presented MEMS QCM biosensor has the advantages of compactness, low cost, low power consumption, high sensitivity, and reliability.
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