无毛
皮肤癌
表皮(动物学)
皮肤病科
紫外线b
细胞凋亡
医学
皮肤肿瘤
拉顿
紫外线
癌症研究
嘧啶二聚体
药理学
化学
免疫学
内科学
生物化学
DNA损伤
癌症
癌变
解剖
DNA
光化学
作者
Mou-Tuan Huang,Jian-Guo Xie,Connie B. Lin,Menas G. Kizoulis,Miri Seiberg,Shapiro Stanley S,Allan H. Conney
出处
期刊:Oncology Research
[Cognizant, LLC]
日期:2004-01-01
卷期号:14 (7): 387-397
被引量:17
标识
DOI:10.3727/0965040041292350
摘要
Treatment of female SKH-1 hairless mice with ultraviolet B light twice a week for 20 weeks resulted in a population of tumor-free mice with a high risk of developing skin tumors during the next several months in the absence of additional UVB treatment (high-risk mice). Topical applications of nondenatured soymilk but not heat-denatured soymilk once a day, 5 days a week to these high-risk mice inhibited the formation and growth of skin tumors. Similar topical applications of soybean trypsin inhibitor or Bowman-Birk inhibitor also inhibited the formation and growth of skin tumors, but these agents were less active than nondenatured soymilk. Treatment of miniswine skin with nondenatured soymilk once a day for 5 days prior to UVB irradiation reduced or completely eliminated UVB-induced formation of thymine dimers and apoptotic cells in the epidermis. These data suggest that nondenatured soymilk could be applied to humans to prevent sunlight-induced skin damage and to reduce the risk of skin tumor formation and progression.
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